Oxidative stress in Knee Osteoarthritis

Knee osteoarthritis (KOA), a debilitating joint disease characterized by cartilage degradation, pain, and functional limitations, represents a significant global health burden. For decades, research has primarily focused on biomechanical factors and the inflammatory cascade in its pathogenesis. However, a compelling body of evidence has emerged, highlighting the critical role of oxidative stress – an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defense mechanisms – in the initiation and progression of this complex condition. This book, "Oxidative Stress in Knee Osteoarthritis," aims to provide a comprehensive and up-to-date exploration of this pivotal aspect of KOA. We delve into the intricate molecular mechanisms by which excessive ROS generation damages articular cartilage, subchondral bone, and synovial tissues. From the sources of ROS within the joint microenvironment to the cellular targets of oxidative damage, we meticulously dissect the pathways that contribute to the disease's hallmark features. We extend our sincere gratitude to the numerous researchers whose pioneering work has laid the foundation for our current understanding, and to the contributors who have shared their expertise to make this book a reality.